Shaun is in his mid-life and leads an unexciting and normal life. Working in the same boring place at an electronic store and living and lives with his best friend in the outskirts of the city. Leading a pale life, he constantly neglects his girlfriend, Liz, who works hard to uplift him and to lead a productive life. Because of his negative attitude towards her, she dumps him. Soon after the breakup, he realizes his mistake and plans on winning Liz trust, the only problem between him and his relationship now is that the streets of London are filled with flesh-eating zombies.
As a former London constable, Nicholas Angel finds it difficult to adapt to his new assignment in the sleepy British village of Sandford. Not only does he miss the excitement of the big city, but he also has a well-meaning oaf for a partner. However, when a series of grisly accidents rocks Sandford, Angel smells something rotten in the idyllic village.
Five friends who reunite in an attempt to top their epic pub crawl from 20 years earlier unwittingly become humankind's only hope for survival.